Houston Methodist. Leading Medicine

Knee News

Repeat That Knee Injection, Please!

Injecting a lubricating fluid made from chicken combs has proven helpful for some people with knee osteoarthritis. An injectable drug called Hylan GF-20 is now on the market. A series of three to five weekly injections is given directly into the joint. The injections can give pain relief and increased knee mobility for up to six months. But if symptoms return, can the injections be used again?

Doctors are looking into this question. There is some concern that a local reaction may occur with more than one series of injections. There have been reports of pain, swelling, and loss of motion with this drug. Sometimes, patients can't put weight on their leg because of severe pain.

Research at the William Beaumont Army Medical Center in Texas is being done in this area. Two groups of adults with knee osteoarthritis received Hylan GF-20. One group had a single series of three injections. The other group had two or three more sets of injections. The group with the extra injections had eight times more local reactions than those who only had one set of injections.

Some patients who initially get relief from the injections may want to use them again. However, they should be aware that a reaction to the drug may occur. Repeated injections that cause joint pain, and swelling can otherwise be treated with steroid medication. At this point, there isn't enough research to tell patients not to try the injections a second or third time. They must be alerted, however, about possible problems when making this decision.


Seth S. Leopold, MD, et al. Increased Frequency of Acute Local Reaction To Intra-Articular Hylan GF-20 (Synvisc) in Patients Receiving More Than One Course of Treatment. In The Journal of Bone and Joint Surgery. September 2002. Vol. 84-A. No. 9. Pp. 1619-1623.

09/18/2002

*Disclaimer:* The information contained herein is compiled from a variety of sources. It may not be complete or timely. It does not cover all diseases, physical conditions, ailments or treatments. The information should NOT be used in place of visit with your healthcare provider, nor should you disregard the advice of your health care provider because of any information you read in this topic.
All content provided by eORTHOPOD® is a registered trademark of Medical Multimedia Group, L.L.C.. Content is the sole property of Medical Multimedia Group, LLC and used herein by permission.

Our Specialties

Where Does It Hurt?

Our Locations

  Follow Us

Follow us on Facebook Follow us on YouTube
Follow us on Twitter